The contents of Combigan, brimonidine and timolol, help in reducing the pressure in the eyes. Brimonidine helps by acting on the alpha receptors in the vessels supplying the ciliary body. This leads to the constriction of blood vessels and subsequent reduction in the quantity of the liquid filtering out from blood vessels. This results in reduced formation of aqueous humour (liquid). This way, brimonidine helps in decreasing the intraocular pressure. Timolol, the other content of Combigan, helps in blocking the beta receptors in eyes. This also results in reduction in production of aqueous humour, which in turn, decreases the intraocular pressure. Thus, Combigan helps in treatment of disorders like glaucoma and ocular hypertension. It relieves these conditions by reducing the pressure in the eyes.
How to Use Combigan:
Combigan is available as a local ophthalmic agent. The recommended dose of Combigan is 1 drop, 2 times in a day. There should be a time gap of 12 hours between the two doses of Combigan. Also, if the medicine is used along with other ophthalmic drops, then there should be an interval of 5 minutes between the administrations of the 2 different eye drops.
Combigan Side Effects:
Some of the common side effects of Combigan are mentioned below:
Red eyes due to hyperaemia
Pain and burning in eyes
Blephritis
Swelling of the eyelids
Sleepiness
Weakness and fatigue
Corneal erosion
Depression
Dryness of mouth
Headache
Photophobia
Palpitations
Abnormal taste in mouth
Patients are advised that when they buy Combigan, they should be aware of these side effects and they should contact their health practitioners if they notice these symptoms.
The symptoms of overdose of Combigan include severe headache, dullness, dizziness, difficulty in breathing, slow pulse rate, bronchospasm and even cardiac arrest, in rare cases. If an overdose of Combigan is suspected, the patient should be immediately taken to the hospital. Care should be taken to maintain the patency of the airways. In case of oral overdose of Combigan, a symptomatic and supportive therapy is needed.
Patients should take care to store this medicine in a cool and dry place. It should not be exposed to direct sunlight or heat. Also, care should be taken to keep the medicine away from the reach of small children and pets.
Patients are informed that there are some drug interactions of Combigan. It can cause a severe reaction when it is used along with other medicines that are given below:
Tricyclic antidepressants
Monoamine oxidase inhibitors
Beta blockers
Calcium channel blockers
Digoxin
Anti-arrhythmic agents
Cimetidine
When you make a decision to purchase Combigan, you should inform the physician if you are taking any of the above mentioned medicines. The use of these medicines along with Combigan is to be avoided, to prevent the occurrence of any drug interaction. Also, patients should inform the physician about all the current medications they are taking, like the prescription medicines, non-prescription medicines, supplementary drugs and herbal medicines.
Patients are informed that they can take a missed dose of Combigan soon after they remember. However, if the time for the next scheduled dose of Combigan has reached, then it is better to let go that missed dose and resume the prescribed schedule from the next dose. Patients should never take 2 doses of Combigan at a time to adjust for the missed dose as this can lead to an adverse reaction.
Use of Combigan is restricted in patients suffering from following conditions:
Asthma
Heart disorders leading to AV block
Bradycardia
History of cardiac illnesses
Depression
Diabetes
Hyperthyroidism
Allergic disorders
Patients may have to opt for other medicines or adjust the dose of this medicine if they are suffering from any of these disorders. Also, Combigan is known to cause some harmful effects on the fetus. Hence, its use in pregnant females should be avoided.
It should be remembered that Combigan can cause impairment of the thinking process and alertness. Hence, patients are advised that they should refrain from activities, which need careful attention, like driving a car or working on machines. When you buy Combigan, let the doctor know about all your current medications like pain killers, ophthalmic agents, sedatives and anti-allergy drugs to avoid any adverse reactions.
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Overdose
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Precautions
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